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This is very likely their most significant accomplishment yet. It will have a huge impact on medicine in the coming decades.

https://www.sciencemag.org/news/2020/11/game-has-changed-ai-triumphs-solving-protein-structures

Artificial intelligence (AI) has solved one of biology’s grand challenges: predicting how proteins curl up from a linear chain of amino acids into 3D shapes that allow them to carry out life’s tasks. Today, leading structural biologists and organizers of a biennial protein-folding competition announced the achievement by researchers at DeepMind, a U.K.-based AI company. They say the DeepMind method will have far-reaching effects, among them dramatically speeding the creation of new medications.

https://www.nature.com/articles/d41586-020-03348-4

AlphaFold’s performance also marks a turning point for DeepMind. The company is best known for wielding AI to master games such Go, but its long-term goal is to develop programs capable of achieving broad, human-like intelligence. Tackling grand scientific challenges, such as protein-structure prediction, is one of the most important applications its AI can make, Hassabis says. “I do think it’s the most significant thing we’ve done, in terms of real-world impact.”

https://www.bbc.com/news/science-environment-55133972

"Now that the problem has been largely solved for single proteins, the way is open for development of new methods for determining the shape of protein complexes - collections of proteins that work together to form much of the machinery of life, and for other applications," said Dr Kryshtafovych.