Dendrite Processing

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frankinstien

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Dendrite Processing
« on: November 19, 2021, 05:35:59 am »
Here is a very interesting and fairly recent paper on the morphology and signaling of dendrite spines.

The diagram below is from the article:



Looking at the ion pumps on the plasma membrane and the endoplasmic reticulum (ER) membrane, it's clear, that there is an ability to modulate signaling, allowing either amplification or reduction. Not, only that, but the ability to control a neuron's internal states, such as dichotomies that can act in a boolean fashion where the spine's states can cancel out or re-enforce each other within regions. The paper states that the spines can physically change and that has an effect on the plasticity of neurons.

The beauty of this kind of approach is by simply anchoring to these spines you can build combinational logic astronomically.  :o

Here's an older paper on the effects of caffeine on dendrite spines.

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MikeB

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Re: Dendrite Processing
« Reply #1 on: November 19, 2021, 01:55:29 pm »
Inhibition / excitation (plasticity) of synapses is controlled through Chloride flow, and the Cysteine component in Glutamate (GAD65).

Apples, cranberries, eggs contain the Cysteine amino acid... You can literally eat them and 5 seconds later feel more mentally flexible, sociable, open minded...

Some info here:
"In addition, some EAATs [Excitatory Amino Acid Transporters] also act as chloride channels or mediate the uptake of cysteine, required to produce the reactive oxygen species scavenger glutathione."

https://core.ac.uk/download/pdf/300327899.pdf

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MagnusWootton

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Re: Dendrite Processing
« Reply #2 on: November 19, 2021, 04:49:16 pm »
I dont think the secret of Ai is in studying the brain,    I believe in Socratic thought (Thought with no experiment, its concievable with theory alone, seeing nothing.) to solve it.

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frankinstien

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Re: Dendrite Processing
« Reply #3 on: November 19, 2021, 06:18:47 pm »
I dont think the secret of Ai is in studying the brain,    I believe in Socratic thought (Thought with no experiment, its concievable with theory alone, seeing nothing.) to solve it.

I would disagree, since looking at neurons as state machines and cellular automata removes the stigma and mystery of them. Resolving their behaviors or generalizing them to forms of mathematics that are boolean with a relevance dimension allows for analogies, albeit scaled-down, to current electronics and even digital technologies. Where working with programming languages that can mimic free association, something thought 40 years ago as impossible for a computer, is very possible today using object-oriented relationships and O1 lookups. I don't think we, as a culture would have attempted to do such a thing if it weren't for the research that has revealed, so far, that neurons behave with fuzzy states.

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MagnusWootton

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Re: Dendrite Processing
« Reply #4 on: November 19, 2021, 06:27:16 pm »
You can come up with cellular automata without studying biology at all.   The whole thing of the Turing Machine, was concieved by Alan Turing without studying any biology either.

I hate biology.

Leave the animals alone,    you'll learn nothing you can work out by yourself with their pain, and cruelty towards them.

 


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